Buses from Santa Clarita to San Diego
🚌 The trip from Santa Clarita to San Diego by bus takes approximately 5 hours 12 mins covering a distance of 163 miles with a transfer along the way. 🚌 The first leg of the journey involves a bus towards Los Angeles, departing from Lyons Ave & Valley St and arriving at Alameda / College, taking about 58 mins. The second step is a bus towards San Diego operated by FlixBus, taking around 2 hours 40 mins.