Buses from Rochester to Sioux Falls
🚌 **Starting from Rochester your journey to Sioux Falls by bus will take approximately 1 day and 8 hours, covering a distance of 1,358 miles with 4 transfers along the way.** The first leg of the trip involves boarding a Greyhound bus towards Toronto from Rochester NY Bus Station, with subsequent transfers in Buffalo, Cleveland, Chicago, and Minneapolis before reaching your final destination in Sioux Falls with Jefferson Lines.