Panama City to Fort Myers, FL from $149: 1 ways by bus, train, flight or car

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Get detailed, step-by-step directions below for your trip from Panama City to Fort Myers with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Average Duration

5h  30m

Estimated price

$149-149

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Duration: 5h 30m

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Traveling From Panama City to Fort Myers

This route from Panama City, where vibrant urban life meets rich cultural heritage, to Fort Myers, known for its serene beaches and outdoor adventures, offers you a captivating contrast between bustling city energy and laid-back coastal relaxation.

Best Neighbourhoods in Fort Myers

Fort Myers boasts diverse neighborhoods, each offering something special for visitors.

Downtown Fort Myers

• Vibrant nightlife with restaurants and bars.

• Historical architecture with a lively arts scene.

Fort Myers Beach

• Stunning white sandy beaches perfect for relaxation.

• Exciting water activities like kayaking and parasailing.

Sanibel Island

• Famous for shell collecting along beautiful shores.

• Scenic nature trails and wildlife refuges await exploration.

Best Times To Visit Fort Myers's Attractions

Planning your visit around these tips will enhance your Fort Myers experience.

Edison and Ford Winter Estates

Visit during weekday mornings for a quieter, more personal tour.

Fort Myers Beach

Early mornings and late afternoons offer peaceful beach time and stunning sunsets.

Six Mile Cypress Slough Preserve

Weekdays in the early hours provide peaceful wildlife viewing and fewer crowds.

Fort Myers Weather: What to Expect Year-Round

Fort Myers boasts a warm subtropical climate, with mild winters and hot, humid summers, making it appealing for year-round travel. The best times to visit are typically from November to April, when cooler temperatures enhance outdoor activities and minimize the risk of rain.

Dining Recommendation in Fort Myers

While in Fort Myers, don’t miss trying the fresh catch at Doc Ford's Rum Bar & Grille, where the tropical flavors and laid-back atmosphere offer a pleasant escape from Panama City's vibrant culinary scene. The incorporation of local seafood and spices creates a delightful contrast, giving you a taste of Florida’s coastal charm.