Iowa City, IA, USA to Hannibal, MO, USA from $79: 1 ways by bus, train, flight or car

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Get detailed, step-by-step directions below for your trip from Iowa City to Hannibal with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Average Duration

4h  30m

Estimated price

$79-79

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Distance: 240 km

Duration: 4h 30m

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Traveling From Iowa City to Hannibal

The journey from Iowa City to Hannibal offers a striking contrast between Iowa's vibrant college town atmosphere and Hannibal's quaint, historical charm rooted in Mark Twain's literary legacy.

Best Neighbourhoods in Hannibal

Hannibal's neighborhoods showcase a mix of history, culture, and charm.

Historic District

• Home to the Mark Twain Boyhood Home

• Offers scenic views of the Mississippi River

Downtown Hannibal

• Vibrant shops and local eateries

• Hosts seasonal events and festivals

Riverview Park

• Ideal for picnics and outdoor activities

• Beautiful trails along the riverbank

Best Times To Visit Hannibal's Attractions

Timing your visit to Hannibal's attractions can elevate your experience.

Mark Twain Boyhood Home

Visit in early spring or late fall for smaller crowds.

Cave Hollow West

Go during weekday afternoons in summer for a quieter tour.

Hannibal History Museum

Early mornings are ideal for a peaceful exploration of exhibits.

Hannibal Weather: What to Expect Year-Round

Hannibal experiences a humid continental climate, with warm summers and cold winters, making spring and fall the ideal seasons to visit for comfortable weather. Being aware of local weather patterns can enrich your travel experience, whether you’re exploring outdoor attractions or enjoying the charm of the town.

Dining Recommendation in Hannibal

Indulge in a plate of the award-winning fried catfish at The Rail, a local favorite that showcases Hannibal’s Southern-inspired cuisine and emphasis on fresh, local ingredients. This experience diverges from the diverse dining scene in Iowa City, offering a relaxed and inviting atmosphere where you can savor the rich flavors unique to this river town.