Santa Fe, NM, USA to Guanajuato from $53: 1 ways by bus, train, flight or car

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Get detailed, step-by-step directions below for your trip from Santa Fe to Guanajuato with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Average Duration

4h  30m

Estimated price

$53-53

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Duration: 4h 30m

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Traveling From Santa Fe to Guanajuato

Traveling from Santa Fe to Guanajuato offers a striking contrast: Santa Fe with its high desert charm and artistic flair, and Guanajuato with its vibrant colors, rich history, and a labyrinth of charming streets.

Best Neighbourhoods in Guanajuato

Guanajuato boasts diverse neighborhoods, each offering its own charm and attractions.

Centro Histórico

• Home to iconic landmarks like Teatro Juárez.

• Vibrant street life and numerous dining options.

San Miguel

• Known for stunning colonial architecture.

• Great cafés and art galleries to explore.

Pueblo Nuevo

• A quieter, residential vibe for relaxation.

• Scenic views and local market experiences.

Best Times To Visit Guanajuato's Attractions

Guanajuato's attractions shine at different times, enhancing your travel experience.

Museo de las Momias

Visit in the morning on weekdays for fewer crowds and a peaceful exploration.

Teatro Juárez

Catch a performance in the evening for a spectacular atmosphere and fewer tourists.

Alley of the Kiss

Early mornings or late afternoons provide a quieter backdrop for photos.

Guanajuato Weather: What to Expect Year-Round

Guanajuato enjoys a mild, temperate climate with sunny days and cool nights, making it a pleasant destination year-round. The best times to visit are during the spring and fall when temperatures are comfortable, allowing for enjoyable exploration of the city’s vibrant streets and attractions.

Dining in Guanajuato: A Culinary Adventure

In Guanajuato, treat yourself to "Mole de Caderas," a rich and flavorful dish made from goat meat and local spices, offering a sharp contrast to the New Mexican chile-based cuisine of Santa Fe. Dining here immerses you in an enchanting atmosphere of traditional Mexican hospitality, with local ingredients that elevate each bite, surrounded by the vibrant colors of the city.