
San Francisco, CA, USA to Midwest, , USA from $144: 8 ways by bus, train, flight or car
Compare Travel Options and Prices
How to Get from San Francisco to Midwest: Cheapest, Fastest and Best Way
1Map provides directions to cities, towns, landmarks, attractions, and addresses worldwide, offering thousands of multi-modal routes to easily get you from point A to point B.
Compare Train, Bus, Flight, and Driving Options
Get detailed, step-by-step directions below for your trip from San Francisco to Midwest with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

See more options
Traveling From San Francisco to Midwest
Your journey from the vibrant coastal city of San Francisco to the tranquil expanse of the Midwest reveals a striking contrast between the tech-driven streets of the Bay Area and the charming, slower pace of life found in America’s heartland.
Best Neighborhoods in Midwest
Midwest neighborhoods offer a blend of culture, hospitality, and charm.
Best Times To Visit Midwest's Attractions
Timing your visit to Midwest attractions can significantly enhance your experience.
Midwest Weather: What to Expect Year-Round
The Midwest experiences four distinct seasons, with hot summers and cold winters influencing your travel plans. Visiting during spring or fall can offer milder temperatures and vibrant scenery, enhancing your overall experience.
Dining Recommendation
When in the Midwest, try a classic deep-dish pizza from Lou Malnati's in Chicago, where the layered, hearty flavors and flaky crust create a comforting experience unlike San Francisco's fresh seafood and Asian fusion cuisine. This dining adventure showcases the region's penchant for rich, satisfying meals, often prepared with locally sourced ingredients and served in a cozy, welcoming atmosphere.
San Francisco - Midwest operators
Explore transport companies operating between San Francisco and Midwest, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Train from Civic Center / UN Plaza to Milpitas
Train from Richmond to Sacramento
Train from Richmond to Denver
Bus from San Francisco Bus Station to Bakersfield Train Station
Bus from Las Vegas S Strip Transit Terminal to Denver Union Station
Bus from Denver Union Station to Casper Amtrak Station
Plane from San Francisco (SFO) to Casper (CPR)
Plane from San Francisco to Casper
Plane from San Francisco Airport to Casper Airport
Other from Casper to Midwest
Frequently asked questions
Find out more about the route from San Francisco to Midwest.
Trips from San Francisco
- San Francisco to Las Vegas
- San Francisco to San Jose
- San Francisco to San Bernardino
- San Francisco to Portland
- San Francisco to Los Angeles
- San Francisco to Sonoma
- San Francisco to Carmel-by-the-Sea
- San Francisco to San Diego
- San Francisco to Fresno
- San Francisco to Bakersfield
- San Francisco to Seattle
- San Francisco to Tiburon
- San Francisco to Monterey
- San Francisco to Mendocino
- San Francisco to Mexico City
- San Francisco to Napa
- San Francisco to Fairbanks
- San Francisco to Santa Rosa
- San Francisco to Sacramento
- San Francisco to Miami
- San Francisco to Anchorage
- San Francisco to Atlanta
- San Francisco to Oaxaca
- San Francisco to Houston
- San Francisco to Oakland
- San Francisco to Vallejo
- San Francisco to Stockton
- San Francisco to Santa Clara
- San Francisco to Phuket
- San Francisco to Seoul
- San Francisco to Dallas
- San Francisco to Tulum
- San Francisco to Kalamazoo
- San Francisco to Edinburgh
- San Francisco to Venice
- San Francisco to Paris
- San Francisco to Florence
- San Francisco to Vienna
- San Francisco to Wuhan
- San Francisco to Vaitape