
Port St. Lucie, FL, USA to Key West, FL, USA from $29: 8 ways by bus, train, flight or car
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How to Get from Port St. Lucie to Key West: Cheapest, Fastest and Best Way
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Compare Train, Bus, Flight, and Driving Options
Get detailed, step-by-step directions below for your trip from Port St. Lucie to Key West with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Port St. Lucie to Key West
Traveling from Port St. Lucie to Key West takes you from a serene, family-friendly environment to a lively island atmosphere known for vibrant nightlife and stunning sunsets.
Best Neighbourhoods in Key West
Key West features vibrant neighborhoods, each offering a distinct charm.
Best Times To Visit Key West's Attractions
Timing your visit can enhance your Key West experience significantly.
Key West Weather: What to Expect Year-Round
Key West boasts a tropical climate with warm temperatures year-round, making it a favored destination for sun-seekers. The best times to visit are from December to April, when humidity is lower and outdoor activities are more enjoyable.
Dining Recommendation in Key West
Try the conch fritters at Blue Heaven, where the lively atmosphere offers a charming outdoor setting that contrasts with Port St. Lucie's more subdued dining options. The dish features a delightful blend of local ingredients, delivering a burst of flavor that captures the essence of island cuisine.
Port St. Lucie - Key West operators
Explore transport companies operating between Port St. Lucie and Key West, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Bus from Fort Pierce to Miami Airport
Bus from Fort Pierce to Fort Lauderdale
Bus from Fort Pierce to Orlando RedCoach Station
Bus from Miami Airport Station to Key West
Train from Fort Lauderdale Station to Miami Airport Station
Plane from Miami Airport to Key West Airport
Plane from Orlando to Key West via Miami
Plane from Fort Lauderdale-Hollywood International to Key West
Plane from Orlando to Key West
Other from Fort Pierce to Miami International Airport
Other from Fort Pierce to Fort Lauderdale - Broward Blvd Park and Ride
Other from Fort Pierce to Miami Airport
Other from Fort Pierce to Bayside Marketplace
Other from Bayside Marketplace to Plaza Hotel
Port St. Lucie to Key West: Overview of Bus, Train, Flight, and Car Trips
Traveling between Port St. Lucie and Key West offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Port St. Lucie to Key West.
Trips from Port St. Lucie
- Port St. Lucie to Jacksonville
- Port St. Lucie to Palm Beach Gardens
- Port St. Lucie to Daytona Beach
- Port St. Lucie to Kissimmee
- Port St. Lucie to Naples
- Port St. Lucie to Tampa
- Port St. Lucie to Cocoa Beach
- Port St. Lucie to Boynton Beach
- Port St. Lucie to Gainesville
- Port St. Lucie to Fort Myers
- Port St. Lucie to Melbourne
- Port St. Lucie to Pompano Beach
- Port St. Lucie to Vero Beach
- Port St. Lucie to Jupiter
- Port St. Lucie to Palm Bay
- Port St. Lucie to St. Augustine
- Port St. Lucie to Boca Raton
- Port St. Lucie to Okeechobee
- Port St. Lucie to Orlando
- Port St. Lucie to Sarasota
- Port St. Lucie to Miami
- Port St. Lucie to Fort Pierce
- Port St. Lucie to West Palm Beach
- Port St. Lucie to Tallahassee
- Port St. Lucie to Delray Beach
- Port St. Lucie to Fort Lauderdale
- Port St. Lucie to Ocala
- Port St. Lucie to Atlanta
- Port St. Lucie to Lake Worth Beach
- Port St. Lucie to St. Petersburg
- Port St. Lucie to Spring Hill
- Port St. Lucie to Sebring
- Port St. Lucie to The Villages
- Port St. Lucie to Hollywood
- Port St. Lucie to Immokalee
- Port St. Lucie to Miami Beach
- Port St. Lucie to Jensen Beach
- Port St. Lucie to Sebastian
- Port St. Lucie to Mount Dora
- Port St. Lucie to Brooksville
Trips to Jacksonville
- Tampa to Key West
- Orlando to Key West
- Fort Lauderdale to Key West
- Miami to Key West
- Marco Island to Key West
- Fort Myers to Key West
- Punta Gorda to Key West
- St. Petersburg to Key West
- Pensacola to Key West
- Naples to Key West
- Marathon to Key West
- Havana to Key West
- Sarasota to Key West
- Homestead to Key West
- Siesta Key to Key West
- Miami Beach to Key West
- Chicago to Key West
- Charleston to Key West
- New York City to Key West
- Raleigh to Key West
- New Orleans to Key West
- Houston to Key West
- Nashville to Key West
- Charlotte to Key West
- Atlanta to Key West
- Philadelphia to Key West
- Saint Louis to Key West
- Fort Myers Beach to Key West
- Los Angeles to Key West
- Newark to Key West
- Destin to Key West
- Sunrise to Key West
- Denver to Key West
- Sanford to Key West
- Islamorada to Key West
- Kansas City to Key West
- Key Largo to Key West
- Dallas to Key West
- Largo to Key West
- San Francisco to Key West