
Des Moines, IA, USA to Knoxville, IA, USA from $7: 3 ways by bus, train, flight or car
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How to Get from Des Moines to Knoxville: Cheapest, Fastest and Best Way
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Get detailed, step-by-step directions below for your trip from Des Moines to Knoxville with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Des Moines to Knoxville
Your journey from Des Moines to Knoxville takes you from the vibrant Midwestern charm of Iowa to the scenic beauty and rich history of Tennessee, offering a mix of bustling city life and tranquil outdoor adventures.
Best Neighbourhoods in Knoxville
Knoxville's neighborhoods offer diverse experiences varying from vibrant arts scenes to historical charm.
Best Times To Visit Knoxville's Attractions
Timing your visits can greatly enhance your experience at Knoxville's top attractions.
Knoxville Weather: What to Expect Year-Round
Knoxville experiences a humid subtropical climate, characterized by hot summers and mild winters, making spring and fall the best times to visit for comfortable temperatures. Weather can affect your outdoor plans, so keeping an eye on forecasts ensures you enjoy the city’s scenic beauty to the fullest.
Dining Recommendation in Knoxville
For an unforgettable experience, try the smoked brisket or pulled pork at Sweet P's BBQ, where the rich, smoky flavors and southern cooking techniques stand out in contrast to the Midwestern fare of Des Moines. The vibrant atmosphere and use of locally sourced ingredients create a dining experience that showcases Knoxville's unique culinary heritage.
Des Moines - Knoxville operators
Explore transport companies operating between Des Moines and Knoxville, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Taxi from Des Moines to Knoxville
Taxi from Des Moines to Knoxville
Des Moines to Knoxville: Overview of Bus, Train, Flight, and Car Trips
Traveling between Des Moines and Knoxville offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Des Moines to Knoxville.
Trips from Des Moines
- Des Moines to Chicago
- Des Moines to Ames
- Des Moines to Pella
- Des Moines to Indianola
- Des Moines to Marshalltown
- Des Moines to Osceola
- Des Moines to Newton
- Des Moines to Fort Dodge
- Des Moines to Kansas City
- Des Moines to Waterloo
- Des Moines to Mason City
- Des Moines to Cedar Rapids
- Des Moines to Peoria
- Des Moines to Moline
- Des Moines to Okoboji
- Des Moines to New Orleans
- Des Moines to Minneapolis
- Des Moines to Lincoln
- Des Moines to Milwaukee
- Des Moines to Perry
- Des Moines to Rochester
- Des Moines to New York City
- Des Moines to Nashville
- Des Moines to Sioux Falls
- Des Moines to Seattle
- Des Moines to San Diego
- Des Moines to Las Vegas
- Des Moines to Dallas
- Des Moines to Atlanta
- Des Moines to Indianapolis
- Des Moines to Saint Louis
- Des Moines to Omaha
- Des Moines to Sioux City
- Des Moines to Madison
- Des Moines to Kansas City
- Des Moines to Sigourney
- Des Moines to Iowa City
- Des Moines to Greenfield
- Des Moines to Albia
- Des Moines to Idaho Falls