
Knoxville, TN, USA to Winston-Salem, NC, USA from $93: 5 ways by bus, train, flight or car
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How to Get from Knoxville to Winston-Salem: Cheapest, Fastest and Best Way
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Get detailed, step-by-step directions below for your trip from Knoxville to Winston-Salem with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Knoxville to Winston-Salem
The journey from Knoxville, with its vibrant arts scene and mountain backdrop, to Winston-Salem, known for its rich history in tobacco and Moravian culture, offers starkly different yet equally captivating experiences.
Best Neighbourhoods in Winston-Salem
Winston-Salem's neighborhoods offer a blend of culture, history, and charm.
Best Times To Visit Winston-Salem's Attractions
Timing your visits can enhance your experience at Winston-Salem's top attractions.
Winston-Salem Weather: What to Expect Year-Round
Winston-Salem features a humid subtropical climate, with hot summers and mild winters, making spring and fall the best times to visit for comfortable weather. Understanding the seasonal changes helps better plan your activities, whether it's enjoying outdoor festivals or cozying up in local eateries.
Dining Recommendation in Winston-Salem
Try the Moravian chicken pie at the iconic Old Salem Tavern, where traditional recipes and local ingredients create a distinct culinary experience. Unlike Knoxville’s barbecue-centric scene, this dish reflects Winston-Salem's rich heritage and offers a taste of the unique flavors that define the region.
Knoxville - Winston-Salem operators
Explore transport companies operating between Knoxville and Winston-Salem, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Plane from Knoxville (TYS) to Charlotte (CLT)
Plane from Knoxville (TYS) to Greensboro/High Point via Charlotte
Plane from Knoxville (TYS) to Greensboro/High Point via Reagan Washington
Plane from Knoxville (TYS) to Charlotte via Atlanta
Plane from Knoxville (TYS) to Greensboro/High Point via Atlanta
Plane from Knoxville (TYS) to Greensboro/High Point via Orlando Sanford
Plane from Knoxville (TYS) to Greensboro/High Point via St. Petersburg
Bus from Asheville to Winston Salem(Trans Center)
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
Bus from Willie Brooks BBQ - Boone to Charlotte Airport
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
Shuttle from Hot Springs, NC to Black Bear Resort
Shuttle from Black Bear Resort to Sams Gap
Shuttle from Black Bear Resort to Boone
Taxi from Sams Gap to Asheville
Knoxville to Winston-Salem: Overview of Bus, Train, Flight, and Car Trips
Traveling between Knoxville and Winston-Salem offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Knoxville to Winston-Salem.
Trips from Knoxville
- Knoxville to Chicago
- Knoxville to Gatlinburg
- Knoxville to New Orleans
- Knoxville to Cookeville
- Knoxville to Franklin
- Knoxville to New York City
- Knoxville to Memphis
- Knoxville to Roanoke
- Knoxville to Huntsville
- Knoxville to Kingsport
- Knoxville to Indianapolis
- Knoxville to Raleigh
- Knoxville to Cincinnati
- Knoxville to Orlando
- Knoxville to Jackson
- Knoxville to Sevierville
- Knoxville to Columbia
- Knoxville to Louisville
- Knoxville to Asheville
- Knoxville to Destin
- Knoxville to Phoenix
- Knoxville to Charleston
- Knoxville to Birmingham
- Knoxville to Myrtle Beach
- Knoxville to Pensacola
- Knoxville to Greenville
- Knoxville to Denver
- Knoxville to Boston
- Knoxville to Pigeon Forge
- Knoxville to Johnson City
- Knoxville to Lexington
- Knoxville to Fort Lauderdale
- Knoxville to Dallas
- Knoxville to Nashville
- Knoxville to Miami
- Knoxville to Charlotte
- Knoxville to Omaha
- Knoxville to Chattanooga
- Knoxville to North Myrtle Beach
- Knoxville to Lexington
Trips to Chicago
- Blacksburg to Winston-Salem
- Chapel Hill to Winston-Salem
- Raleigh to Winston-Salem
- Roanoke to Winston-Salem
- Washington to Winston-Salem
- Richmond to Winston-Salem
- Greenville to Winston-Salem
- Nashville to Winston-Salem
- Greenville to Winston-Salem
- Lexington to Winston-Salem
- Atlanta to Winston-Salem
- Cary to Winston-Salem
- Philadelphia to Winston-Salem
- Boone to Winston-Salem
- Myrtle Beach to Winston-Salem
- Charlotte to Winston-Salem
- Columbia to Winston-Salem
- New York City to Winston-Salem
- Orlando to Winston-Salem
- Virginia Beach to Winston-Salem
- Statesville to Winston-Salem
- Asheville to Winston-Salem
- Kernersville to Winston-Salem
- Durham to Winston-Salem
- Wilmington to Winston-Salem
- Wilmington to Winston-Salem
- Burlington to Winston-Salem
- Wilkesboro to Winston-Salem
- Salisbury to Winston-Salem
- Jacksonville to Winston-Salem
- Indianapolis to Winston-Salem
- Miami to Winston-Salem
- Greensboro to Winston-Salem
- Mebane to Winston-Salem
- Fayetteville to Winston-Salem
- Clemson to Winston-Salem
- High Point to Winston-Salem
- Clarksburg to Winston-Salem
- Seneca to Winston-Salem
- Mocksville to Winston-Salem