Medellin, Antioquia to Santiago de Cali, Valle del Cauca from $38: 1 ways by bus, train, flight or car

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Get detailed, step-by-step directions below for your trip from Medellin to Santiago de Cali with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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various

Bus

Average Duration

10h  30m

Estimated price

$38-38

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Distance: 440 km

Duration: 10h 30m

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Traveling From Medellin to Santiago de Cali

The journey from Medellin to Santiago de Cali offers a striking contrast, as you transition from the vibrant, mountainous landscapes and innovative spirit of Medellin to the warm, salsa-infused culture and riverside charm of Cali.

Best Neighbourhoods in Santiago de Cali

Santiago de Cali boasts diverse neighborhoods, each with its own charm and vibe.

San Antonio

• Known for its bohemian atmosphere and art galleries.

• Offers stunning views from the hilltop.

Granada

• Home to upscale dining and trendy cafes.

• Vibrant nightlife scene with lively bars.

El Peñón

• Charming streets lined with colorful houses.

• Close to the river and scenic parks.

Best Times To Visit Santiago de Cali's Attractions

Timing your visits can elevate your Santiago de Cali experience.

Cali Zoo

Visiting in the morning on weekdays offers a quieter experience with active animals.

Cristo Rey

Sunrise or late afternoon visits provide stunning views and fewer tourists.

Plaza de Caicedo

Weekdays during lunch hours are lively, yet less crowded for photos.

Santiago de Cali Weather: What to Expect Year-Round

Santiago de Cali enjoys a tropical climate with warm temperatures throughout the year, making it generally pleasant for travelers. The dry season from December to March is ideal for outdoor activities and festivals, while occasional rainy periods can bring a refreshing break to your adventures.

Dining Recommendation in Santiago de Cali

Try 'sancocho de gallina' at La Casa de los Abuelos, a hearty chicken soup loaded with local vegetables, offering a comforting taste that stands apart from Medellin's traditional paisa fare. The vibrant atmosphere and focus on fresh, regional ingredients bring out the distinct, rich flavors of Cali's culinary heritage.