
New Orleans, LA, USA to Knoxville, TN, USA from $143: 6 ways by bus, train, flight or car
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How to Get from New Orleans to Knoxville: Cheapest, Fastest and Best Way
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Compare Train, Bus, Flight, and Driving Options
Get detailed, step-by-step directions below for your trip from New Orleans to Knoxville with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From New Orleans to Knoxville
The journey from New Orleans to Knoxville offers you a delightful contrast between the vibrant, jazz-infused streets of the Big Easy and the charming, mountain-laden landscapes of East Tennessee.
Best Neighbourhoods in Knoxville
Knoxville features diverse neighborhoods, each with its own character and charm.
Best Times To Visit Knoxville's Attractions
Timing your visits can greatly enhance your experience at Knoxville's popular sites.
Knoxville Weather: What to Expect Year-Round
Knoxville experiences a humid subtropical climate, characterized by hot summers and mild winters, making spring and fall some of the best seasons to visit. The weather can influence your travel plans, so being aware of seasonal changes helps you enjoy outdoor activities and local festivals.
Dining Recommendation in Knoxville
For a true taste of Knoxville, try the smoky flavors of a barbecue platter at Sweet P’s Barbeque & Soul House, where the slow-cooked meats feature rich local spices and sauces. This experience stands apart from New Orleans’ vibrant Creole dishes, offering a relaxed atmosphere with a focus on comforting, hearty southern fare that celebrates local ingredients.
New Orleans - Knoxville operators
Explore transport companies operating between New Orleans and Knoxville, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Plane from New Orleans (MSY) to Knoxville (TYS)
Plane from Gulfport/Biloxi (GPT) to Knoxville (TYS)
Plane from Baton Rouge (BTR) to Knoxville (TYS)
Plane from New Orleans (MSY) to Knoxville (TYS)
Plane from Gulfport/Biloxi (GPT) to Knoxville (TYS)
Plane from Baton Rouge (BTR) to Knoxville (TYS)
Plane from New Orleans (MSY) to Knoxville (TYS)
Plane from Gulfport/Biloxi (GPT) to Knoxville (TYS)
Plane from Baton Rouge (BTR) to Knoxville (TYS)
Train from New Orleans Union Passenger Terminal to Charlotte Amtrak Station
Train from New Orleans Union Passenger Terminal to Lynchburg
Bus from Charlotte Airport to Blowing Rock - Tanger Outlets
Bus from Lynchburg Transit Center to Greeneville
Shuttle from Black Bear Resort to Hot Springs, NC
Taxi from Blowing Rock - Tanger Outlets to Black Bear Resort
New Orleans to Knoxville: Overview of Bus, Train, Flight, and Car Trips
Traveling between New Orleans and Knoxville offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from New Orleans to Knoxville.
Trips from New Orleans
- New Orleans to Gulfport
- New Orleans to Slidell
- New Orleans to Orlando
- New Orleans to Hattiesburg
- New Orleans to LaPlace
- New Orleans to Miami
- New Orleans to Dallas
- New Orleans to Rosemary Beach
- New Orleans to Lafayette
- New Orleans to Shreveport
- New Orleans to Pensacola
- New Orleans to Nashville
- New Orleans to Lake Charles
- New Orleans to Washington
- New Orleans to Memphis
- New Orleans to Little Rock
- New Orleans to Galveston
- New Orleans to Kansas City
- New Orleans to Tampa
- New Orleans to Gulf Shores
- New Orleans to Destin
- New Orleans to Alexandria
- New Orleans to New York City
- New Orleans to Austin
- New Orleans to Jackson
- New Orleans to Birmingham
- New Orleans to Chattanooga
- New Orleans to Atlanta
- New Orleans to Mobile
- New Orleans to Houma
- New Orleans to Fort Lauderdale
- New Orleans to Panama City
- New Orleans to Pensacola Beach
- New Orleans to Cancun
- New Orleans to Biloxi
- New Orleans to Venice
- New Orleans to Houston
- New Orleans to Baton Rouge
- New Orleans to Chicago
- New Orleans to Punta Cana
Trips to Gulfport
- Chicago to Knoxville
- Memphis to Knoxville
- Nashville to Knoxville
- Chattanooga to Knoxville
- Roanoke to Knoxville
- Atlanta to Knoxville
- Charlotte to Knoxville
- Cookeville to Knoxville
- Asheville to Knoxville
- Johnson City to Knoxville
- Philadelphia to Knoxville
- Dallas to Knoxville
- Louisville to Knoxville
- Raleigh to Knoxville
- Tampa to Knoxville
- Miami to Knoxville
- Boston to Knoxville
- Austin to Knoxville
- Orlando to Knoxville
- Lexington to Knoxville
- Los Angeles to Knoxville
- Indianapolis to Knoxville
- Sevierville to Knoxville
- Houston to Knoxville
- Minneapolis to Knoxville
- Denver to Knoxville
- Savannah to Knoxville
- Gatlinburg to Knoxville
- Pigeon Forge to Knoxville
- Cincinnati to Knoxville
- Lexington to Knoxville
- Charleston to Knoxville
- Greenville to Knoxville
- Charleston to Knoxville
- Huntsville to Knoxville
- Crossville to Knoxville
- Jackson to Knoxville
- Greenville to Knoxville
- Louisville to Knoxville
- Salt Lake City to Knoxville