Chillicothe, MO, USA to Des Moines, IA, USA from $75: 3 ways by bus, train, flight or car

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Get detailed, step-by-step directions below for your trip from Chillicothe to Des Moines with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Various

Bus

Average Duration

3h  30m

Estimated price

$83-83

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Company

Various

Bus

Average Duration

4h 

Estimated price

$75-75

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Distance: 280 km

Duration: 3h 30m

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Company

Various

Train

Average Duration

5h  15m

Estimated price

$90-90

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Traveling From Chillicothe to Des Moines

Traveling from Chillicothe to Des Moines offers a fascinating shift from the small-town charm of Chillicothe to the vibrant urban scene of Iowa’s capital.

Best Neighbourhoods in Des Moines

Des Moines boasts diverse neighborhoods, each with its own character and attractions.

Downtown Des Moines

• Home to vibrant arts and culture scenes.

• Excellent dining and nightlife options.

Historic Valley Junction

• Unique shops and boutiques line the streets.

• Frequent community events and farmers' markets.

East Village

• Trendy cafes and local boutiques abound.

• Close proximity to major attractions and venues.

Best Times To Visit Des Moines's Attractions

Planning your visit around peak times can enhance your experience in Des Moines.

Iowa State Capitol

Visit early mornings during weekdays for fewer crowds and peace.

Pappajohn Sculpture Park

Late afternoons on weekdays offer a quieter atmosphere for art lovers.

Des Moines Farmers' Market

Arrive right at opening on Saturdays for the best selection and fewer people.

Des Moines Weather: What to Expect Year-Round

Des Moines experiences a humid continental climate, with hot summers and cold winters, making it essential to choose your travel time wisely. Spring and fall are particularly pleasant, offering comfortable temperatures and stunning scenery, but be prepared for sudden weather changes at any time.

Dining Recommendation in Des Moines

You shouldn't miss the chance to try the farm-to-table experience at the trendy restaurant, Farm Bar, where the seasonal dishes burst with bold flavors and utilize fresh local ingredients. This atmosphere, combining rustic charm with modern flair, stands in stark contrast to Chillicothe's more traditional dining scene, offering you an exciting culinary adventure.