
Charleston, SC, USA to Des Moines, IA, USA from $130: 6 ways by bus, train, flight or car
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How to Get from Charleston to Des Moines: Cheapest, Fastest and Best Way
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Get detailed, step-by-step directions below for your trip from Charleston to Des Moines with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Charleston to Des Moines
Traveling from Charleston to Des Moines showcases a blend of Southern charm and Midwestern resilience, allowing you to enjoy the historic coastal vibes of Charleston before immersing yourself in the vibrant urban culture and scenic landscapes of Des Moines.
Best Neighborhoods in Des Moines
Des Moines features diverse neighborhoods that offer distinct vibes and attractions.
Best Times To Visit Des Moines's Attractions
Timing your visit can greatly enhance your experience at Des Moines's attractions.
Des Moines Weather: What to Expect Year-Round
Des Moines experiences four distinct seasons, with hot summers and cold winters, making spring and fall the most pleasant times to visit. Be prepared for varied weather conditions, as extremes can impact outdoor activities and travel plans.
Dining in Des Moines: A Taste of the Midwest
Try the iconic pork tenderloin sandwich at the Iowa State Fairgrounds, a dish that's beloved in Des Moines and differs greatly from Charleston's seafood-centric offerings. This hearty sandwich, often served with a crisp coating and toppings, reflects the local farm-to-table ethos and offers a casual dining atmosphere that contrasts with Charleston's historic fine dining scene.
Charleston - Des Moines operators
Explore transport companies operating between Charleston and Des Moines, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Plane from Charleston (CHS) to Des Moines (DSM)
Plane from Charleston (CHS) to Des Moines (DSM)
Plane from Charleston (CHS) to Des Moines (DSM)
Train from Charleston Amtrak Station to Washington Union Station
Train from Rockville Amtrak to Chicago Union Station
Train from Chicago Union Station to Galesburg Amtrak Station
Bus from Charleston to New York
Bus from Galesburg, Il to Burlington, Ia
Bus from Burlington, Ia to Des Moines, Ia
Bus from Chicago, Il to Des Moines, Ia
Bus from New York City Chinatown to Washington Union Station
Bus from Washington Union Station to Chicago Bus Station
Charleston to Des Moines: Overview of Bus, Train, Flight, and Car Trips
Traveling between Charleston and Des Moines offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Charleston to Des Moines.
Trips from Charleston
- Charleston to Bluffton
- Charleston to Tybee Island
- Charleston to New York City
- Charleston to Orlando
- Charleston to Miami
- Charleston to Myrtle Beach
- Charleston to Folly Beach
- Charleston to Charlotte
- Charleston to Greenville
- Charleston to Savannah
- Charleston to Key West
- Charleston to Richmond
- Charleston to Florence
- Charleston to Jacksonville
- Charleston to Denver
- Charleston to Asheville
- Charleston to Hilton Head Island
- Charleston to West Palm Beach
- Charleston to Memphis
- Charleston to Seattle
- Charleston to Las Vegas
- Charleston to Fort Lauderdale
- Charleston to Summerville
- Charleston to St. Augustine
- Charleston to Nashville
- Charleston to Philadelphia
- Charleston to Raleigh
- Charleston to Knoxville
- Charleston to Clemson
- Charleston to Augusta
- Charleston to Norfolk
- Charleston to Louisville
- Charleston to Daufuskie Island
- Charleston to Phoenix
- Charleston to Columbia
- Charleston to Dallas
- Charleston to Beaufort
- Charleston to London
- Charleston to Pawleys Island
- Charleston to Kiawah Island
Trips to Bluffton
- Chicago to Des Moines
- Minneapolis to Des Moines
- Dubuque to Des Moines
- Pella to Des Moines
- Indianapolis to Des Moines
- Davenport to Des Moines
- Oskaloosa to Des Moines
- Madison to Des Moines
- Peoria to Des Moines
- Milwaukee to Des Moines
- Detroit to Des Moines
- New York City to Des Moines
- Lincoln to Des Moines
- Omaha to Des Moines
- Kearney to Des Moines
- Iowa City to Des Moines
- San Antonio to Des Moines
- Boston to Des Moines
- Seattle to Des Moines
- Houston to Des Moines
- Boone to Des Moines
- Saint Louis to Des Moines
- Ames to Des Moines
- Harpers Ferry to Des Moines
- Mason City to Des Moines
- Perry to Des Moines
- Dallas to Des Moines
- Story City to Des Moines
- Moline to Des Moines
- Charles City to Des Moines
- Cedar Rapids to Des Moines
- Waterloo to Des Moines
- Greenfield to Des Moines
- Kansas City to Des Moines
- Atlantic to Des Moines
- Burlington to Des Moines
- Denison to Des Moines
- Eagle Grove to Des Moines
- Lincoln to Des Moines
- Kansas City to Des Moines