
Pittsburgh, PA, USA to Knoxville, TN, USA from $121: 6 ways by bus, train, flight or car
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How to Get from Pittsburgh to Knoxville: Cheapest, Fastest and Best Way
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Get detailed, step-by-step directions below for your trip from Pittsburgh to Knoxville with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Pittsburgh to Knoxville
Journeying from Pittsburgh to Knoxville showcases a striking contrast between Pittsburgh's industrial charm and Knoxville's southern hospitality.
Best Neighborhoods in Knoxville
Knoxville boasts diverse neighborhoods that cater to various interests and experiences.
Best Times To Visit Knoxville's Attractions
Timing your visits can greatly enhance your experience in Knoxville.
Knoxville Weather: What to Expect Year-Round
Knoxville experiences a humid subtropical climate, featuring warm summers and mild winters, making spring and fall the best times for outdoor activities. Seasonal weather influences your travel plans, with summer offering vibrant festivals and winter showcasing cozy indoor events.
Dining in Knoxville: A Unique Culinary Experience
Sampling the smoky, slow-cooked barbecue at Sweet P's Barbeque & Soul House provides a flavorful contrast to Pittsburgh's hearty, meat-and-potatoes meals. This vibrant eatery emphasizes local ingredients and southern hospitality, creating an atmosphere that celebrates the region's culinary traditions.
Pittsburgh - Knoxville operators
Explore transport companies operating between Pittsburgh and Knoxville, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Plane from Pittsburgh (PIT) to Knoxville (TYS)
Plane from Pittsburgh (PIT) to Knoxville (TYS)
Plane from Pittsburgh (PIT) to Knoxville (TYS)
Train from Pittsburgh Amtrak Station to Washington Union Station
Train from Washington Union Station to Lynchburg
Train from Pittsburgh Amtrak Station to New York Penn Station
Bus from Monroeville, PA to New York
Bus from Pittsburgh Intermodal Station to Washington Union Station
Bus from Washington Union Station to Richmond Bus Station
Bus from Richmond Bus Station to Greeneville
Pittsburgh to Knoxville: Overview of Bus, Train, Flight, and Car Trips
Traveling between Pittsburgh and Knoxville offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Pittsburgh to Knoxville.
Trips from Pittsburgh
- Pittsburgh to Boston
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- Pittsburgh to Erie
Trips to Boston
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- Charleston to Knoxville
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- Louisville to Knoxville
- Salt Lake City to Knoxville