
Charleston, SC, USA to Winston-Salem, NC, USA from $28: 7 ways by bus, train, flight or car
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How to Get from Charleston to Winston-Salem: Cheapest, Fastest and Best Way
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Compare Train, Bus, Flight, and Driving Options
Get detailed, step-by-step directions below for your trip from Charleston to Winston-Salem with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From Charleston to Winston-Salem
Traveling from Charleston to Winston-Salem offers a striking transition from the coastal charm and historic elegance of the Lowcountry to the vibrant arts and heritage of the Piedmont region.
Best Neighbourhoods in Winston-Salem
Winston-Salem boasts diverse neighborhoods, each with its own charm and character.
Best Times To Visit Winston-Salem's Attractions
Planning your visit wisely can enhance your experience at Winston-Salem's attractions.
Winston-Salem Weather: What to Expect Year-Round
Winston-Salem experiences a humid subtropical climate, allowing for four distinct seasons with hot summers and mild winters. Spring and fall are often considered the best times to visit, as pleasant temperatures and lower humidity create an enjoyable travel experience.
Dining Recommendation in Winston-Salem
In Winston-Salem, try the smoked brisket at a local barbecue spot, which showcases a rich, smoky flavor that differs from Charleston's seafood-centric cuisine. This dining experience allows you to savor the region's love for slow-cooked meats, complemented by a lively atmosphere filled with Southern hospitality.
Charleston - Winston-Salem operators
Explore transport companies operating between Charleston and Winston-Salem, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Train from Charleston Amtrak Station to Selma
Train from Selma to Greensboro
Train from Charleston Amtrak Station to Fayetteville Amtrak Station
Bus from Charleston Bus Station to Raleigh Bus Station
Bus from Raleigh Bus Station to Winston Salem(Trans Center)
Bus from Greensboro Bus Stop to Winston Salem(Trans Center)
Bus from Fayetteville to Winston-Salem
Bus from Charlotte Bus Station to Winston Salem(Trans Center)
Plane from Charleston (CHS) to Greensboro/High Point (GSO)
Plane from Charleston (CHS) to Greensboro/High Point (GSO)
Charleston to Winston-Salem: Overview of Bus, Train, Flight, and Car Trips
Traveling between Charleston and Winston-Salem offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from Charleston to Winston-Salem.
Trips from Charleston
- Charleston to Bluffton
- Charleston to Tybee Island
- Charleston to New York City
- Charleston to Orlando
- Charleston to Miami
- Charleston to Myrtle Beach
- Charleston to Folly Beach
- Charleston to Charlotte
- Charleston to Greenville
- Charleston to Edisto Island
- Charleston to Savannah
- Charleston to Richmond
- Charleston to Florence
- Charleston to Jacksonville
- Charleston to Tampa
- Charleston to Wilmington
- Charleston to Denver
- Charleston to Asheville
- Charleston to Isle of Palms
- Charleston to Greenville
- Charleston to Hilton Head Island
- Charleston to New Orleans
- Charleston to Seattle
- Charleston to Las Vegas
- Charleston to Columbia
- Charleston to Fort Lauderdale
- Charleston to Summerville
- Charleston to BERMUDA
- Charleston to Nashville
- Charleston to Philadelphia
- Charleston to Raleigh
- Charleston to Knoxville
- Charleston to Clemson
- Charleston to Augusta
- Charleston to Louisville
- Charleston to Daufuskie Island
- Charleston to Phoenix
- Charleston to Columbia
- Charleston to Beaufort
- Charleston to Pawleys Island
Trips to Bluffton
- Blacksburg to Winston-Salem
- Chapel Hill to Winston-Salem
- Raleigh to Winston-Salem
- Roanoke to Winston-Salem
- Washington to Winston-Salem
- Richmond to Winston-Salem
- Greenville to Winston-Salem
- Nashville to Winston-Salem
- Greenville to Winston-Salem
- Lexington to Winston-Salem
- Atlanta to Winston-Salem
- Cary to Winston-Salem
- Philadelphia to Winston-Salem
- Boone to Winston-Salem
- Myrtle Beach to Winston-Salem
- Charlotte to Winston-Salem
- Columbia to Winston-Salem
- New York City to Winston-Salem
- Knoxville to Winston-Salem
- Statesville to Winston-Salem
- Asheville to Winston-Salem
- Kernersville to Winston-Salem
- Durham to Winston-Salem
- Wilmington to Winston-Salem
- Wilmington to Winston-Salem
- Burlington to Winston-Salem
- Wilkesboro to Winston-Salem
- Salisbury to Winston-Salem
- Jacksonville to Winston-Salem
- Indianapolis to Winston-Salem
- Miami to Winston-Salem
- Greensboro to Winston-Salem
- Mebane to Winston-Salem
- Fayetteville to Winston-Salem
- Clemson to Winston-Salem
- High Point to Winston-Salem
- Clarksburg to Winston-Salem
- Seneca to Winston-Salem
- Mocksville to Winston-Salem
- Las Vegas to Winston-Salem