
San Diego, CA, USA to Knoxville, TN, USA from $1861: 6 ways by bus, train, flight or car
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How to Get from San Diego to Knoxville: Cheapest, Fastest and Best Way
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Compare Train, Bus, Flight, and Driving Options
Get detailed, step-by-step directions below for your trip from San Diego to Knoxville with 1Map travel planner. Easily compare ticket prices, explore various transport options, and find the best routes for a seamless and cost-effective travel experience.

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Traveling From San Diego to Knoxville
The journey from San Diego to Knoxville offers a striking contrast between the sun-soaked beaches of Southern California and the lush, vibrant landscapes of Tennessee, providing travelers with a blend of coastal relaxation and Southern charm.
Best Neighbourhoods in Knoxville
Knoxville's neighborhoods offer diverse experiences, rich culture, and local charm.
Best Times To Visit Knoxville's Attractions
Timing your visits can greatly enhance your experience in Knoxville.
Knoxville Weather: What to Expect Year-Round
Knoxville experiences a humid subtropical climate, featuring warm summers and mild winters, making spring and fall the best times to visit with comfortable temperatures. Understanding seasonal weather patterns can help you pack appropriately and plan activities to maximize your enjoyment during your trip.
Dining Recommendation in Knoxville
Try the signature dish at Blackberry Farm, where the focus on farm-to-table Southern cuisine stands in stark contrast to San Diego's fresh seafood and tacos. The rich flavors of locally sourced ingredients and the rustic, cozy atmosphere provide a refreshing and unique culinary experience that embodies the heart of Tennessee.
San Diego - Knoxville operators
Explore transport companies operating between San Diego and Knoxville, with prices starting at . These companies offer competitive pricing, flexible schedules, and comfortable travel experiences.
Plane from San Diego (SAN) to Knoxville (TYS)
Plane from San Diego (SAN) to Asheville (AVL)
Plane from San Diego (SAN) to Knoxville (TYS)
Plane from San Diego (SAN) to Asheville (AVL)
Plane from San Diego (SAN) to Knoxville (TYS)
Plane from San Diego (SAN) to Asheville (AVL)
Train from San Diego to Los Angeles
Train from Los Angeles to Dallas
Train from Dallas to New Orleans Union Passenger Terminal
Train from New Orleans Union Passenger Terminal to Charlotte Amtrak Station
Bus from San Diego to Los Angeles Downtown
Bus from Los Angeles Union Station to Dallas Bus Station
Bus from Los Angeles Union Station to Dallas Bus Station
Bus from Dallas Bus Station to Nashville Bus Station
Bus from Nashville Bus Station to Greeneville
Other from Charlotte Airport to Blowing Rock - Tanger Outlets
Other from Black Bear Resort to Hot Springs, NC
Other from Blowing Rock - Tanger Outlets to Black Bear Resort
Other from Blowing Rock - Tanger Outlets to Black Bear Resort
San Diego to Knoxville: Overview of Bus, Train, Flight, and Car Trips
Traveling between San Diego and Knoxville offers a variety of convenient options to suit your preferences, schedule, and budget. Whether you prioritize affordability, speed, or comfort, you’re sure to find the perfect way to travel without compromising on quality or convenience.
Frequently asked questions
Find out more about the route from San Diego to Knoxville.
Trips from San Diego
- San Diego to Irvine
- San Diego to San Clemente
- San Diego to Long Beach
- San Diego to Carlsbad
- San Diego to Riverside
- San Diego to Santa Monica
- San Diego to Pasadena
- San Diego to Newport Beach
- San Diego to Monterey
- San Diego to Mexico City
- San Diego to Santa Ana
- San Diego to Anaheim
- San Diego to Temecula
- San Diego to Albuquerque
- San Diego to Ensenada
- San Diego to San Jose
- San Diego to Los Angeles
- San Diego to San Francisco
- San Diego to San Luis Obispo
- San Diego to Bakersfield
- San Diego to Santa Barbara
- San Diego to Las Vegas
- San Diego to San Bernardino
- San Diego to San Antonio
- San Diego to Seattle
- San Diego to Yuma
- San Diego to Tijuana
- San Diego to Salt Lake City
- San Diego to Cabo San Lucas
- San Diego to Toronto
- San Diego to Miami
- San Diego to Tampa
- San Diego to Austin
- San Diego to Puerto Vallarta
- San Diego to Oceanside
- San Diego to Fort Lauderdale
- San Diego to Madrid
- San Diego to Orange
- San Diego to Avalon
- San Diego to Paris
Trips to Irvine
- Chicago to Knoxville
- New Orleans to Knoxville
- Memphis to Knoxville
- Nashville to Knoxville
- Chattanooga to Knoxville
- Roanoke to Knoxville
- Atlanta to Knoxville
- Charlotte to Knoxville
- Cookeville to Knoxville
- Asheville to Knoxville
- Johnson City to Knoxville
- Philadelphia to Knoxville
- Dallas to Knoxville
- Louisville to Knoxville
- Raleigh to Knoxville
- Tampa to Knoxville
- Miami to Knoxville
- Boston to Knoxville
- Austin to Knoxville
- Orlando to Knoxville
- Lexington to Knoxville
- Los Angeles to Knoxville
- Indianapolis to Knoxville
- Sevierville to Knoxville
- Houston to Knoxville
- Minneapolis to Knoxville
- Denver to Knoxville
- Gatlinburg to Knoxville
- Pigeon Forge to Knoxville
- Cincinnati to Knoxville
- Lexington to Knoxville
- Charleston to Knoxville
- Greenville to Knoxville
- Charleston to Knoxville
- Huntsville to Knoxville
- Crossville to Knoxville
- Jackson to Knoxville
- Greenville to Knoxville
- Louisville to Knoxville
- Salt Lake City to Knoxville